تفاعل #595388

معادلة التفاعل

benzyl 4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-1H-indazol-3-yl)-2-(hydroxymethyl)benzoate

Dess-Martin periodinane

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benzyl 4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-1H-indazol-3-yl)-2-formylbenzoate

المذيبات

H2O

DCM

ظروف التفاعل

المعالجة

1. 1
   استخلاصextracted with DCM
2. 2
   غسيلThe combined organic layers were washed with brine
3. 3
   تجفيفdried over Na2SO4
4. 4
   تركيزconcentrated
5. 5
   أخرىThe resulting crude oil was used in the next step without further purification

الإجراء التجريبي

To a mixture of benzyl 4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-1H-indazol-3-yl)-2-(hydroxymethyl)benzoate (G-3) (0.4 g, 0.71 mmol) in DCM (10 mL) was added Dess-Martin periodinane (0.45 g, 1.07 mmol), and the mixture was stirred at rt for 24 h. The mixture was diluted with H2O and extracted with DCM. The combined organic layers were washed with brine, dried over Na2SO4 and concentrated. The resulting crude oil was used in the next step without further purification. LCMS (ESI)′ calc'd for C30H19ClF3N2O4 [M+H]+: 563. found: 563.

المصدر