تفاعل #595376

معادلة التفاعل

3-bromo-1H-indazole

triethylamine

2-cyanobenzene-1-sulfonyl chloride

→

3-bromo-1-(2-cyanophenylsulfonyl)-1H-indazole

المردود 97.4%

المذيبات

CH2Cl2

ظروف التفاعل

المعالجة

1. 1
   تركيزAfter completion the reaction mixture was concentrated under reduced pressure
2. 2
   أخرىthe product was purified on SiO2 using 0% to 50% ethyl acetate in heptane as the eluent

الإجراء التجريبي

To a solution of 3-bromo-1H-indazole (200 mg, 1.02 mmol) in 2 ml CH2Cl2 was added triethylamine (308 mg, 3.05 mmol) and 2-cyanobenzene-1-sulfonyl chloride (205 mg, 1.02 mmol). The reaction mixture was stirred overnight at room temperature. After completion the reaction mixture was concentrated under reduced pressure and the product was purified on SiO2 using 0% to 50% ethyl acetate in heptane as the eluent to give 3-bromo-1-(2-cyanophenylsulfonyl)-1H-indazole (360 mg) as a yellow solid.

المصدر