تفاعل #595358

معادلة التفاعل

compound

2-Amino-4-[4-(2-hydroxyethoxy)phenyl]-6-mercaptopyridine-3,5-dicarbonitrile

compound

4-(Chloromethyl)-2-(4-chloro-3-methylphenyl)-1,3-oxazole

sodium bicarbonate

→

2-Amino-6-({[2-(4-chloro-3-methylphenyl)-1,3-oxazol-4-yl]methyl}thio)-4-[4-(2-hydroxyethoxy)-phenyl]pyridine-3,5-dicarbonitrile

المذيبات

DMF

ظروف التفاعل

المعالجة

1. 1
   ترشيحThe mixture is then filtered
2. 2
   أخرىthe filtrate is purified directly by preparative HPLC (column: YMC GEL ODS-AQ S-5/15 μm; mobile phase gradient: acetonitrile/water 10:90→95:5)
3. 3
   أخرىAfter removal of the solvent
4. 4
   أخرىon a rotary evaporator
5. 5
   أخرىthe product is obtained as a white solid

الإجراء التجريبي

52 mg (0.17 mmol) of the compound from Example 1A and 89 mg (0.18 mmol) of the compound from Example 28A, together with 42 mg (0.50 mmol) of sodium bicarbonate, are suspended in 1.8 ml of dry DMF. The reaction mixture is stirred at RT for 12 h. The mixture is then filtered and the filtrate is purified directly by preparative HPLC (column: YMC GEL ODS-AQ S-5/15 μm; mobile phase gradient: acetonitrile/water 10:90→95:5). After removal of the solvent on a rotary evaporator, the product is obtained as a white solid.

المصدر