تفاعل #595353

معادلة التفاعل

compound

Methyl 2-(4-chlorophenyl)-4-(hydroxymethyl)-1,3-oxazole-5-carboxylate

thionyl chloride

→

Methyl 4-(chloromethyl)-2-(4-chlorophenyl)-1,3-oxazole-5-carboxylate

ظروف التفاعل

المعالجة

1. 1
   أخرىThe excess thionyl chloride is removed under reduced pressure
2. 2
   غسيلThe mixture is washed once with 2 ml of sat. aqueous sodium bicarbonate solution
3. 3
   تجفيفThe organic phase is dried over magnesium sulfate
4. 4
   أخرىthe solvent is removed under reduced pressure
5. 5
   أخرىThe product obtained
6. 6
   أخرىis used without further purification in the subsequent reactions

الإجراء التجريبي

100 mg (0.43 mmol) of the compound from Example 44A, together with 0.24 ml (3.24 mmol) of thionyl chloride, are stirred at RT for 8 h. The excess thionyl chloride is removed under reduced pressure and the residue is taken up in about 5 ml of ethyl acetate. The mixture is washed once with 2 ml of sat. aqueous sodium bicarbonate solution. The organic phase is dried over magnesium sulfate and the solvent is removed under reduced pressure. The product obtained is used without further purification in the subsequent reactions.

المصدر