تفاعل #595352

معادلة التفاعل

compound

Methyl 2-(4-chlorophenyl)-4-[(methoxymethoxy)methyl]-1,3-oxazole-5-carboxylate

hydrochloric acid

→

Methyl 2-(4-chlorophenyl)-4-(hydroxymethyl)-1,3-oxazole-5-carboxylate

المذيبات

methanol

water

ظروف التفاعل

المعالجة

1. 1
   استخلاصextracted three times with in each case 10 ml of diethyl ether
2. 2
   تجفيفThe combined organic phases are dried over magnesium sulfate
3. 3
   أخرىthe solvent is removed on a rotary evaporator
4. 4
   أخرىThe product obtained
5. 5
   أخرىis used without further purification in the subsequent reaction

الإجراء التجريبي

144 mg (0.52 mmol) of the compound from Example 43A are initially charged in 0.5 ml of methanol, and 0.13 ml of 4 N hydrochloric acid are added. 3 drops of conc. hydrochloric acid are then added. The reaction mixture is stirred at RT for 8 h. The mixture is then diluted with about 5 ml of water and extracted three times with in each case 10 ml of diethyl ether. The combined organic phases are dried over magnesium sulfate and the solvent is removed on a rotary evaporator. The product obtained is used without further purification in the subsequent reaction.

المصدر