تفاعل #595333

معادلة التفاعل

3-fluoro-4-hydroxybenzaldehyde

2-bromoethanol

potassium carbonate

→

3-Fluoro-4-(2-hydroxyethoxy)benzaldehyde

المذيبات

DMF

ظروف التفاعل

المعالجة

1. 1
   ترشيحThe mixture is then filtered
2. 2
   أخرىthe filtrate is freed from the solvent on a rotary evaporator
3. 3
   workup.ADDITION20 ml of sat. aqueous sodium bicarbonate solution are added
4. 4
   أخرىThe phases are separated
5. 5
   تجفيفthe organic phase is dried over magnesium sulfate
6. 6
   أخرىThe solvent is removed on a rotary evaporator
7. 7
   أخرىThe product obtained
8. 8
   أخرىis used without further purification in the subsequent reaction

الإجراء التجريبي

5.00 g (35.69 mmol) of 3-fluoro-4-hydroxybenzaldehyde are dissolved in 50 ml of dry DMF. 5.35 g (42.82 mmol) of 2-bromoethanol and 19.73 g (142.74 mmol) of potassium carbonate are added. The reaction mixture is stirred at 150° C. for 10 h. The mixture is then filtered, and the filtrate is freed from the solvent on a rotary evaporator. The residue is taken up in 30 ml of ethyl acetate, and 20 ml of sat. aqueous sodium bicarbonate solution are added. The phases are separated and the organic phase is dried over magnesium sulfate. The solvent is removed on a rotary evaporator. The product obtained is used without further purification in the subsequent reaction.

المصدر