تفاعل #595321

معادلة التفاعل

Cyclopropanesulfonyl chloride

BuOH

pyridine

→

oil

المردود 71.0%

Butyl cyclopropanesulfonate

المردود 71.0%

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةThe mixture was slowly warmed at room temperature
2. 2
   أخرىThe solvent was removed under reduced pressure
3. 3
   workup.DISSOLUTIONthe resulting white solid was dissolved in CHCl3
4. 4
   غسيلThe organic phase was washed with water, brine
5. 5
   تجفيفdried (MgSO4)
6. 6
   تركيزconcentrated

الإجراء التجريبي

Cyclopropanesulfonyl chloride (5 g, 35 mmol, 1 eq) was dissolved in an excess BuOH (20 ml), the reaction mixture was cooled at −10° C. and pyridine (5.8 mL, 70 mmol, 2 eq) was slowly added dropwise. The mixture was slowly warmed at room temperature and stirred overnight. The solvent was removed under reduced pressure and the resulting white solid was dissolved in CHCl3. The organic phase was washed with water, brine and dried (MgSO4) and concentrated to give an oil (4.8 g, 24.9 mmol, 71%). 1H NMR (300 MHz, CDCl3): δ 4.25 (t, 2H), 2.46 (m, 1H), 1.74 (m, 2H), 1.45 (m, 2H), 1.25 (dd, 2H), 1.09 (dd, 2H), 0.93 (t, 3H).

المصدر