تفاعل #59501

معادلة التفاعل

6-Phenyl-5,6,7,8-tetrahydro-naphthalen-2-ol

2-chloro-5-nitropyridine

potassium fluoride

HCl

→

5-Nitro-2-(6-phenyl-5,6,7,8-tetrahydro-naphthalen-2-yloxy)-pyridine

المذيبات

dimethylformamide

Water

ظروف التفاعل

المعالجة

1. 1
   استخلاصthe mixture extracted with ethyl acetate
2. 2
   غسيلEthyl acetate was washed with brine and water
3. 3
   أخرىdried
4. 4
   أخرىevaporated
5. 5
   أخرىThe product was recrystallised from toluene

الإجراء التجريبي

6-Phenyl-5,6,7,8-tetrahydro-naphthalen-2-ol (30 mg), 2-chloro-5-nitropyridine (21 mg) and potassium fluoride (23 mg) in dry dimethylformamide were heated at 120° C. until disappearance of the starting material. Water and 1 N HCl were added and the mixture extracted with ethyl acetate. Ethyl acetate was washed with brine and water, dried and evaporated. The product was recrystallised from toluene. 1H NMR (400 MHz, d6-DMSO) δ: 9.04 (d, 1H, J 2.4 Hz), 8.61 (dd, 1H, J 9.0, 2.5), 7.18-7.35 (m, 7H), 6.95-6.99 (m, 2H), 2.83-3.01 (m, 5H), 1.87-2.04 (m, 2H).

المصدر