تفاعل #59487

معادلة التفاعل

2-(3-fluorophenyl)chroman-6-ol

2-(2-fluorophenyl)chroman-4,6diol

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2-(2-Fluorophenyl)chroman-6-ol

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الإجراء التجريبي

2-(2-Fluorophenyl)chroman-6-ol was prepared as described for 2-(3-fluorophenyl)chroman-6-ol in Example 9(c) starting from 800 mg of 2-(2-fluorophenyl)chroman-4,6diol. 1H NMR (300 MHz, d6-DMSO) δ: 7.50 (m, 1H), 7.39 (m, 1H), 7.26-7.19 (m, 2H), 6.63 (m, 1H), 6.53-6.50 (m, 2H), 5.21 (dd, 1H, J, 10.2, 2.3 Hz), 2.98 (ddd, 1H, J −16.9, 11.2, 6.0 Hz), 2.66 (ddd, 1H, J −16.9, 5.0, 2.9 Hz), 2.11 (m, 1H), 1.99 (m, 1H).

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