تفاعل #59401

معادلة التفاعل

(R)-1-carbomethoxymethyl-3-(5-chloroindole-2-carbonylamino)-3,4-dihydrocarbostyril

Lithium hydroxide monohydrate

hydrochloric acid

→

title compound

المردود 95.6%

(R)-1-carboxymethyl-3-(5-chloroindole-2-carbonylamino)-3,4-dihydrocarbostyril

المردود 95.6%

المذيبات

tetrahydrofuran

methanol

water

ظروف التفاعل

المعالجة

1. 1
   استخلاصwas followed by extraction with ethyl acetate (20 mL twice)
2. 2
   غسيلThe combined organic layers were washed with brine (10 mL)
3. 3
   تجفيفdried over anhydrous sodium sulfate
4. 4
   أخرىevaporated under vacuum

الإجراء التجريبي

(R)-1-carbomethoxymethyl-3-(5-chloroindole-2-carbonylamino)-3,4-dihydrocarbostyril (Example 7) (13 mg) was dissolved in a 2:2:1 mixture of tetrahydrofuran, methanol, and water (5 mL). Lithium hydroxide monohydrate (3 mg) was added, and the resulting mixture was stirred at room temperature for 2 h. Addition of 1.0 M aqueous hydrochloric acid (10 mL) was followed by extraction with ethyl acetate (20 mL twice). The combined organic layers were washed with brine (10 mL), dried over anhydrous sodium sulfate, and evaporated under vacuum to provide the title compound (12 mg). HPLC/MS [M+H]+, 398.

المصدر