تفاعل #593881

ord-a98c7f31d9eb43729b726b4f67a8be49

معادلة التفاعل

CC(C)N1CCC(Oc2ccc3c(c2)cc2n3CCNC2=O)CC1
8-(1-isopropyl-piperidin-4-yloxy)-3,4-dihydro-2H-pyrazino[1,2-a]indol-1-one
CC(C)N1CCC(Oc2ccc3c(c2)cc2n3CCNC2=O)CC1
8-(1-Isopropyl-piperidin-4-yloxy)-3,4-dihydro-2H-pyrazino[1,2-a]indol-1-one
[H-].[Na+]
sodium hydride
COc1ccccc1CCl
2-methoxybenzyl chloride
COc1ccccc1CN1CCn2c(cc3cc(OC4CCN(C(C)C)CC4)ccc32)C1=O
desired product
المردود 54.0%
COc1ccccc1CN1CCn2c(cc3cc(OC4CCN(C(C)C)CC4)ccc32)C1=O
8-(1-Isopropyl-piperidin-4-yloxy)-2-(2-methoxy-benzyl)-3,4-dihydro-2H-pyrazino[1,2-a]indol-1-one
المردود 54.0%

ظروف التفاعل

الظروف التفصيلية
See reaction.notes.procedure_details.

الإجراء التجريبي

The title compound was synthesized in analogy to example 17, from 8-(1-isopropyl-piperidin-4-yloxy)-3,4-dihydro-2H-pyrazino[1,2-a]indol-1-one (example 1), sodium hydride and 2-methoxybenzyl chloride, to give the desired product as a white solid (54%).

المصدر

DOI: 10.6084/m9.figshare.5104873.v1براءة الاختراع: US07786109B2uspto-grants-2010_08