تفاعل #5938

معادلة التفاعل

2-aminothiophenol

sodium acetate

methyl α-bromo-4-fluorophenylacetate

→

2-(4-fluorophenyl)-3-oxo-3,4-dihydro-2H-1,4-benzothiazine

المردود 87.6%

المذيبات

ethanol

ظروف التفاعل

المعالجة

1. 1
   workup.DISTILLATIONAfter the solvent is distilled off
2. 2
   workup.ADDITIONwater is added to the residue
3. 3
   أخرىThe resulting precipitate is separated by filtration
4. 4
   غسيلwashed
5. 5
   أخرىdried
6. 6
   أخرىrecrystallized from tetrahydrofuran-n-hexane

الإجراء التجريبي

To a suspension of 2-aminothiophenol (12.6 g) and sodium acetate (23.6 g) in ethanol (150 ml) is added methyl α-bromo-4-fluorophenylacetate (23.6 g), and the mixture is stirred at room temperature overnight. After the solvent is distilled off, water is added to the residue. The resulting precipitate is separated by filtration, washed, dried, and then recrystallized from tetrahydrofuran-n-hexane to give 2-(4-fluorophenyl)-3-oxo-3,4-dihydro-2H-1,4-benzothiazine (21.7 g) as crystals. M.p. 216°-219° C.

المصدر