تفاعل #5929

معادلة التفاعل

1H-naphtho[2,1-b][1,4]thiazin-2(3H)-one

4-chlorobenzaldehyde

sodium methoxide

dimethylformamide

→

3-(4-chlorobenzylidene)-1H-naphtho[2,1-b][1,4]thiazin-2(3H)-one

المردود 52.8%

المذيبات

water

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةis refluxed for 4.5 hours
2. 2
   درجة الحرارةAfter cooling
3. 3
   أخرىthe resulting precipitate is separated by filtration
4. 4
   غسيلwashed
5. 5
   أخرىdried
6. 6
   أخرىis recrystallized from tetrahydrofuran-n-hexane

الإجراء التجريبي

A mixture of 1H-naphtho[2,1-b][1,4]thiazin-2(3H)-one (5.17 g), 4-chlorobenzaldehyde (5.62 g), sodium methoxide (1.73 g) and dimethylformamide (80 ml) is refluxed for 4.5 hours. After cooling, the reaction mixture is poured into water and the resulting precipitate is separated by filtration, washed and dried and then is recrystallized from tetrahydrofuran-n-hexane to give 3-(4-chlorobenzylidene)-1H-naphtho[2,1-b][1,4]thiazin-2(3H)-one (4.28 g). M.p. 277°-279° C.

المصدر