تفاعل #5923

معادلة التفاعل

4-bromobutyryl chloride

2-(4-chlorophenyl)-3,4-dihydro2H-1,4-benzothiazine

sodium hydrogen carbonate

→

4-(4-bromobutyryl)-2-(4-chlorophenyl)-3,4-dihyro-2H-1,4-benzothiazine

المردود 93.2%

المذيبات

ethyl acetate

ethyl acetate

ظروف التفاعل

المعالجة

1. 1
   غسيلThe ethyl acetate layer is washed
2. 2
   أخرىdried
3. 3
   workup.DISTILLATIONdistilled
4. 4
   أخرىto remove the solvent
5. 5
   أخرىThe residue is recrystallized from ethyl acetate-n-hexane

الإجراء التجريبي

To a mixture of 2-(4-chlorophenyl)-3,4-dihydro2H-1,4-benzothiazine (1.08 g), ethyl acetate (20 ml) and aqueous sodium hydrogen carbonate solution (20 ml) is added dropwise a solution of 4-bromobutyryl chloride (0.97 g) in ethyl acetate (5 ml) with stirring under ice cooling. The ethyl acetate layer is washed, dried and distilled to remove the solvent. The residue is recrystallized from ethyl acetate-n-hexane to give 4-(4-bromobutyryl)-2-(4-chlorophenyl)-3,4-dihyro-2H-1,4-benzothiazine (1.58 g, yield 93%).

المصدر