تفاعل #592255

معادلة التفاعل

2-[6-Chloro-3-(2,2,2-trifluoro-acetyl)-indol-1-yl]-N-methyl-acetamide

sodium trimethylsilanolate

→

title compound

المردود 27.0%

6-Chloro-1-methylcarbamoylmethyl-1H-indole-3-carboxylic acid

المردود 27.0%

المذيبات

DCE

ظروف التفاعل

المعالجة

1. 1
   تركيزthe mixture was concentrated in vacuo
2. 2
   أخرىpurified by prep

الإجراء التجريبي

2-[6-Chloro-3-(2,2,2-trifluoro-acetyl)-indol-1-yl]-N-methyl-acetamide was suspensed in DCE and treated with (2.2 eq.) of sodium trimethylsilanolate. After shaking at room temperature for 20 min, the mixture was concentrated in vacuo and purified by prep. HPLC to give the title compound in 27% yield.

المصدر