تفاعل #5912

معادلة التفاعل

2-Chloroquinoxaline

sodium hydrosulphide

→

solid

المردود 157.3%

2-mercaptoquinoxaline

المردود 157.3%

المذيبات

dimethylformamide

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةto cool
2. 2
   أخرىpartitioned between 70 ml of water and 30 ml of ethyl acetate
3. 3
   أخرىThe organic layer was separated
4. 4
   استخلاصthe aqueous layer extracted twice with 20 ml of ethyl acetate
5. 5
   غسيلThe combined organic extracts were washed with sodium chloride solution
6. 6
   تجفيفdried over anhydrous magnesium sulphate
7. 7
   ترشيحfiltered
8. 8
   أخرىthe solvent removed under reduced pressure

الإجراء التجريبي

2-Chloroquinoxaline (2 g) and sodium hydrosulphide (1.23 g) were stirred together in 25 ml of dimethylformamide and heated to 100° C. After 3 hours the reaction mixture was allowed to cool and then partitioned between 70 ml of water and 30 ml of ethyl acetate. The organic layer was separated and the aqueous layer extracted twice with 20 ml of ethyl acetate. The combined organic extracts were washed with sodium chloride solution, dried over anhydrous magnesium sulphate, filtered and the solvent removed under reduced pressure to yield an orange solid (3.1 g). The product of this reaction was used in the next preparative step without further purification.

المصدر