تفاعل #59072

معادلة التفاعل

3-(tert-butyl)phenylamine

sodium bicarbonate

thiophosgene

→

3-(tert-butyl)benzenisothiocyanate

المذيبات

acetone

ظروف التفاعل

المعالجة

1. 1
   أخرىwas brought to ambient temperature
2. 2
   تركيزconcentrated
3. 3
   أخرىpartitioned between ethyl acetate and water
4. 4
   تجفيفThe organic layer was dried with sodium bicarbonate and sodium sulfate
5. 5
   تركيزconcentrated

الإجراء التجريبي

To 3-(tert-butyl)phenylamine in acetone at 0° C. was added sodium bicarbonate (2 eq) and thiophosgene (2 eq). The mixture was brought to ambient temperature and concentrated and partitioned between ethyl acetate and water. The organic layer was dried with sodium bicarbonate and sodium sulfate and concentrated to yield 3-(tert-butyl)benzenisothiocyanate. MS: MH+=192.

المصدر