تفاعل #590323

معادلة التفاعل

1-(2,2-diethoxyethoxy)-4-fluorobenzene

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title compound

المردود 50.3%

5-Fluoro[b]benzofuran

المردود 50.3%

المذيبات

n-hexane

ظروف التفاعل

المعالجة

1. 1
   workup.ADDITIONAfter the mixture was treated in a sealed tube at 200° C. for 11 hours
2. 2
   ترشيحthe amberlyst 15 was filtered off
3. 3
   أخرىThe solvent was evaporated
4. 4
   أخرىthe crude product was purified
5. 5
   أخرىseparated by silica gel column chromatography (n-hexane)

الإجراء التجريبي

To a solution of 16.0 g of 1-(2,2-diethoxyethoxy)-4-fluorobenzene in 50 ml n-hexane was added 3.2 g of amberlyst 15 at room temperature. After the mixture was treated in a sealed tube at 200° C. for 11 hours, the amberlyst 15 was filtered off. The solvent was evaporated, and the crude product was purified and separated by silica gel column chromatography (n-hexane), to give 4.8 g of the title compound as a colorless oil.

المصدر