تفاعل #59030

معادلة التفاعل

sodium hydroxide

ethyl [2-ethoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy]acetate

Water

ethyl acetate

→

title compound

المردود 64.2%

4-Carboxymethoxy-3-ethoxyphenylboronic acid

المردود 64.2%

المذيبات

ethanol

ظروف التفاعل

المعالجة

1. 1
   أخرىThe aqueous layer was separated
2. 2
   غسيلwashed with ethyl acetate
3. 3
   workup.ADDITIONmade acidic with the addition of 2 mol/L hydrochloric acid
4. 4
   استخلاصextracted with ethyl acetate
5. 5
   تجفيفThe organic layer was dried over anhydrous magnesium sulfate
6. 6
   أخرىThe solvent was evaporated under reduced pressure

الإجراء التجريبي

A 2 mol/L aqueous solution of sodium hydroxide (2.14 mL) was added to a solution of ethyl [2-ethoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy]acetate (0.15 g) in ethanol (10 mL), and the resulting mixture was stirred at 60° C. for 3 hrs. Water and ethyl acetate were added to the reaction mixture. The aqueous layer was separated, washed with ethyl acetate, made acidic with the addition of 2 mol/L hydrochloric acid, and extracted with ethyl acetate. The organic layer was dried over anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure to afford the title compound (0.066 g).

المصدر