تفاعل #59019

معادلة التفاعل

hydrochloric acid

Trifluoromethanesulfonic anhydride

methyl 4-hydroxy-2-methoxybenzoate

pyridine

→

methyl 2-methoxy-4-trifluoromethanesulfonyloxybenzoate

المذيبات

ethyl acetate

methylene chloride

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةcooled
2. 2
   workup.STIRRINGThe mixture was stirred at room temperature for 30 min
3. 3
   استخلاصThe resulting mixture was extracted with ethyl acetate
4. 4
   غسيلThe organic layer was washed with water and brine
5. 5
   تجفيفdried over anhydrous magnesium sulfate
6. 6
   أخرىThe solvent was evaporated under reduced pressure

الإجراء التجريبي

Trifluoromethanesulfonic anhydride (2.24 mL) was added to an ice-cooled mixture of methyl 4-hydroxy-2-methoxybenzoate (2.02 g) and pyridine (0.14 mL) in methylene chloride (15 mL) with stirring. The mixture was stirred at room temperature for 30 min, and poured into a mixture of hydrochloric acid and ethyl acetate. The resulting mixture was extracted with ethyl acetate. The organic layer was washed with water and brine, and dried over anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure to afford methyl 2-methoxy-4-trifluoromethanesulfonyloxybenzoate (3.49 g).

المصدر