تفاعل #59015

معادلة التفاعل

ethyl acetate

4-bromo-2-isopropylphenyl methanesulfonate

1,3-bis(diphenylphosphino)propane

triethylamine

dimethylsulfoxide

→

title compound

Methyl 4-bromo-2-isopropylbenzoate

المذيبات

Water

methanol

ظروف التفاعل

المعالجة

1. 1
   أخرىThe organic layer was separated
2. 2
   غسيلwashed with water and brine
3. 3
   تجفيفdried over anhydrous magnesium sulfate
4. 4
   أخرىThe solvent was evaporated under reduced pressure
5. 5
   أخرىthe residue was purified by silica gel column chromatography (eluent: diethyl ether/n-hexane=1/10)

الإجراء التجريبي

A mixture of 4-bromo-2-isopropylphenyl methanesulfonate (0.71 g), palladium acetate (0.023 g), 1,3-bis(diphenylphosphino)propane (0.042 g) and triethylamine (0.63 mL) in methanol (6 mL)/dimethylsulfoxide (9 mL) was stirred overnight at 55° C. under an atmosphere of carbon monoxide. Water and ethyl acetate were added to the reaction mixture. The organic layer was separated, washed with water and brine, and dried over anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure, and the residue was purified by silica gel column chromatography (eluent: diethyl ether/n-hexane=1/10) to afford the title compound (0.355 g).

المصدر