تفاعل #59014

معادلة التفاعل

hydrochloric acid

Trifluoromethanesulfonic anhydride

4-bromo-2-isopropylphenol

pyridine

→

4-bromo-2-isopropylphenyl methanesulfonate

المذيبات

ethyl acetate

methylene chloride

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةcooled
2. 2
   workup.STIRRINGThe mixture was stirred for 10 min
3. 3
   أخرىThe organic layer was separated
4. 4
   غسيلwashed with water and brine
5. 5
   تجفيفdried over anhydrous magnesium sulfate
6. 6
   أخرىThe solvent was evaporated under reduced pressure
7. 7
   أخرىthe residue was purified by silica gel column chromatography (eluent: diethyl ether/n-hexane=1/10)

الإجراء التجريبي

Trifluoromethanesulfonic anhydride (0.47 mL) was added to an ice-cooled mixture of 4-bromo-2-isopropylphenol (0.5 g) and pyridine (0.28 mL) in methylene chloride (5 mL) with stirring. The mixture was stirred for 10 min, and poured into a mixture of ethyl acetate and 1 mol/L hydrochloric acid. The organic layer was separated, washed with water and brine, and dried over anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure, and the residue was purified by silica gel column chromatography (eluent: diethyl ether/n-hexane=1/10) to afford 4-bromo-2-isopropylphenyl methanesulfonate (0.71 g).

المصدر