تفاعل #590084

معادلة التفاعل

isopropyl amine

2,4-difluoro-1-nitrobenzene

K2CO3

→

title compound

المردود 88.3%

(5-fluoro-2-nitrophenyl)isopropylamine

المردود 88.3%

المذيبات

THF

THF

ظروف التفاعل

المعالجة

1. 1
   أخرىthe insoluble materials were removed by pad of Celite

الإجراء التجريبي

To a stirred mixture of 2,4-difluoro-1-nitrobenzene (4.77 g, 30 mmol) and K2CO3 (4.14 g, 30 mmol) in THF (30 mL) was added isopropyl amine (1.77 g, 30 mmol) in THF (10 mL) at 0° C. After being stirred for 13 h, the insoluble materials were removed by pad of Celite and the filtrate was consentrated under reduced pressure to give title compound (5.25 g, 88%) as a pale yellow oil.

المصدر