تفاعل #58920

معادلة التفاعل

4-nitrobenzaldehyde

1,3-thiazolidine-2,4-dione

piperidine

→

5-(4-nitrobenzylidene)-1,3-thiazolidine-2,4-dione

المردود 59.2%

المذيبات

ethanol

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةwas heated
2. 2
   درجة الحرارةunder reflux for 24 hrs
3. 3
   تركيزThe reaction mixture was concentrated
4. 4
   غسيلThe obtained residue was washed with ethanol

الإجراء التجريبي

A mixture of 4-nitrobenzaldehyde (15.1 g), 1,3-thiazolidine-2,4-dione (11.70 g), piperidine (1.70 g) and ethanol (300 mL) was heated under reflux for 24 hrs. The reaction mixture was concentrated. The obtained residue was washed with ethanol to give 5-(4-nitrobenzylidene)-1,3-thiazolidine-2,4-dione as yellow crystals (14.8 g, yield 59%). Recrystallization thereof from acetone-hexane gave pale-yellow prism crystals. melting point: 272-273° C.

المصدر