تفاعل #58911

معادلة التفاعل

hydrochloric acid

4-(4-fluorophenyl)-4H-1,2,4-triazole-3-carbaldehyde

ethyl diethylphosphonoacetate

sodium hydride

→

(2E)-3-[4-(4-fluorophenyl)-4H-1,2,4-triazol-3-yl]acrylic acid

المردود 77.1%

المذيبات

tetrahydrofuran

ظروف التفاعل

المعالجة

1. 1
   استخلاصthe mixture was extracted with ethyl acetate
2. 2
   غسيلThe ethyl acetate layer was washed with saturated brine
3. 3
   تجفيفdried over anhydrous magnesium sulfate
4. 4
   تركيزconcentrated
5. 5
   workup.DISSOLUTIONThe residue was dissolved in a 6N aqueous hydrochloric acid solution (100 ml)
6. 6
   workup.STIRRINGstirred for 2 hrs
7. 7
   درجة الحرارةwith heating
8. 8
   درجة الحرارةunder reflux
9. 9
   workup.ADDITIONDisodium hydrogen phosphate was added
10. 10
    ترشيحThe precipitated solids were collected by filtration
11. 11
    غسيلwashed with water
12. 12
    أخرىdried

الإجراء التجريبي

A mixture of 4-(4-fluorophenyl)-4H-1,2,4-triazole-3-carbaldehyde (3.83 g), ethyl diethylphosphonoacetate (5.60 g), sodium hydride (60% in oil, 0.88 g) and tetrahydrofuran (130 ml) was stirred at 0° C. for 1 hr. The reaction mixture was poured into an aqueous dilute hydrochloric acid solution and the mixture was extracted with ethyl acetate. The ethyl acetate layer was washed with saturated brine, dried over anhydrous magnesium sulfate and concentrated. The residue was dissolved in a 6N aqueous hydrochloric acid solution (100 ml) and stirred for 2 hrs. with heating under reflux. Disodium hydrogen phosphate was added to neutralize the reaction mixture. The precipitated solids were collected by filtration, washed with water and dried to give (2E)-3-[4-(4-fluorophenyl)-4H-1,2,4-triazol-3-yl]acrylic acid (3.60 g, yield 76%) as pale-yellow crystals. melting point: 226-229° C. (recrystallized from ethyl acetate-hexane).

المصدر