تفاعل #589017

معادلة التفاعل

2-(4-Acetylaminophenoxy)-propionic acid methyl ester

2-(4-Acetylamino-phenoxy)-propionic acid methyl ester

→

9

المردود 98.1%

2-(4-Amino-phenoxy)-propionic acid

المردود 98.1%

المذيبات

HCl

ظروف التفاعل

المعالجة

1. 1
   workup.DISTILLATIONExcess conc. HCl was distilled off in vacuum
2. 2
   ترشيحfiltered hot
3. 3
   ترشيحfiltered
4. 4
   أخرىdried

الإجراء التجريبي

2-(4-Acetylaminophenoxy)-propionic acid methyl ester 8 (320 g, 1.35 mol) in conc. HCl (8 L) was refluxed for 48 hours. Excess conc. HCl was distilled off in vacuum and filtered hot. The mixture was cooled to 10° C., filtered and dried to give pure 9 (240 g, 81.7%) as a brown powder with an m.p between 175-180° C.

المصدر