تفاعل #58716

معادلة التفاعل

N-(4-chloro-phenyl)-8-hydroxy -quinoline-2-carboxamidine

K2CO3

iodomethane

→

N-(4-chloro-phenyl)-8-methoxy -quinoline-2-carboxamidine

المردود 45.7%

المذيبات

DMF

NaHCO3

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةwas heated under microwave (100 W, 5 min)
2. 2
   استخلاصextracted with three 10 mL portions of ether
3. 3
   غسيلThe combined organic extracts were washed with 10 mL of brine
4. 4
   تجفيفdried over Na2SO4
5. 5
   ترشيحfiltered
6. 6
   تركيزconcentrated
7. 7
   أخرىThe residue was purified by preparative TLC
8. 8
   غسيلeluting with 20% ethyl acetate in hexanes

الإجراء التجريبي

A mixture of 0.10 g (0.33 mmol) of N-(4-chloro-phenyl)-8-hydroxy -quinoline-2-carboxamidine, 0.137 g (1 mmol) of K2CO3 and 0.021 g (0.33 mmol) of iodomethane in 3.5 mL of DMF was heated under microwave (100 W, 5 min). It was diluted with 20 mL of NaHCO3, extracted with three 10 mL portions of ether. The combined organic extracts were washed with 10 mL of brine, dried over Na2SO4, filtered and concentrated. The residue was purified by preparative TLC eluting with 20% ethyl acetate in hexanes to give 0.047 g of N-(4-chloro-phenyl)-8-methoxy -quinoline-2-carboxamidine.

المصدر