تفاعل #587094

معادلة التفاعل

ethyl 1-methyl-4-[({[4-(trifluoromethoxy)phenyl]amino}carbonyl)amino]-1H-imidazole-2-carboxylate

Ethyl 1-methyl-4-[({[4-(trifluoromethoxy)phenyl]amino}carbonyl)amino]-1H-imidazole-2-carboxylate

sodium hydroxide

hydrochloric acid

→

1-Methyl-4-[({[4-(trifluoromethoxy)phenyl]amino}carbonyl)amino]-1H-imidazole-2-carboxylic Acid

المذيبات

ethanol

tetrahydrofuran

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةWhile cooling in ice
2. 2
   درجة الحرارةwhile cooling in ice
3. 3
   استخلاصThe solution is extracted with dichloromethane
4. 4
   تركيزThe organic phase is concentrated in vacuo
5. 5
   أخرىThe residue is purified by preparative HPLC

الإجراء التجريبي

835 mg (2.13 mmol) of ethyl 1-methyl-4-[({[4-(trifluoromethoxy)phenyl]amino}carbonyl)amino]-1H-imidazole-2-carboxylate (Example 28A) are suspended in 5 ml of ethanol and 12 ml of tetrahydrofuran. While cooling in ice, 2 ml (25 mmol) of 50% strength aqueous sodium hydroxide solution are added. The reaction mixture is stirred at room temperature overnight and then, while cooling in ice, acidified with 1N hydrochloric acid. The solution is extracted with dichloromethane. The organic phase is concentrated in vacuo. The residue is purified by preparative HPLC.

المصدر