تفاعل #58634

معادلة التفاعل

N-methoxy-N-methylacetamide

3-bromobenzylmagnesium bromide

→

title compound

1-(3-bromophenyl)acetone

المذيبات

ether

ظروف التفاعل

المعالجة

1. 1
   أخرىthe reaction mixture was partitioned between hexane and saturated aqueous ammonium chloride
2. 2
   أخرىThe organic layer was separated
3. 3
   غسيلwashed with brine
4. 4
   تجفيفdried over anhydrous magnesium sulfate
5. 5
   ترشيحfiltered
6. 6
   تركيزconcentrated to dryness

الإجراء التجريبي

To a solution of N-methoxy-N-methylacetamide (10 g, 0.10 mol) in 200 mL of ether at 0° C. was added 3-bromobenzylmagnesium bromide (0.25 M, 200 mL, 50 mmol). After stirring at 0° C. for 2 h, the reaction mixture was partitioned between hexane and saturated aqueous ammonium chloride. The organic layer was separated, washed with brine, dried over anhydrous magnesium sulfate, filtered and concentrated to dryness to give the title compound, which was used without further purification. 1H NMR (500 MHz, CD3OD): δ 7.5-7.1 (m, 4H), 3.78 (s, 2H), 2.19 (s, 3H).

المصدر