تفاعل #58633

ord-ee4d69775b564da7a71cc7f3e764aaac

معادلة التفاعل

CC(C)(C)OC(=O)N1CC(C(=O)O)C1
1-tert-butoxycarbonylazetidine-3-carboxylic acid
CC(C)(C)OC(=O)N1CCC1C(=O)O
1-tert-butoxycarbonylazetidine-2-carboxylic acid
→
CCC1(C(=O)O)CCN1C(=O)OC(C)(C)C
title compound
CCC1(C(=O)O)CCN1C(=O)OC(C)(C)C
1-tert-Butoxycarbonyl-2-ethylazetidine-2-carboxylic Acid

المتفاعلات

CC(C)(C)OC(=O)N1CC(C(=O)O)C1
1-tert-butoxycarbonylazetidine-3-carboxylic acid
CC(C)(C)OC(=O)N1CCC1C(=O)O
1-tert-butoxycarbonylazetidine-2-carboxylic acid

الكواشف

لا شيء

ظروف التفاعل

الظروف التفصيلية
See reaction.notes.procedure_details.

الإجراء التجريبي

The title compound was prepared following the procedure described for Reference Example 15 substituting 1-tert-butoxycarbonylazetidine-3-carboxylic acid with 1-tert-butoxycarbonylazetidine-2-carboxylic acid at Step A. 1H NMR (500 MHz, CD3OD): δ 3.98-3.90 (m, 1H), 3.80-3.62 (m, 1H), 2.36-1.82 (m, 4H), 1.42 (s, 9H), 1.02 (t, 3H).

المصدر

DOI: 10.6084/m9.figshare.5104873.v1براءة الاختراع: US07423067B2uspto-grants-2008_09