تفاعل #586102

معادلة التفاعل

N-(2-methyl-3-(1,1-dimethylpropyl)phenyl)form-amide

potassium hydroxide

methanol

→

3-(1,1-dimethypropyl)-2-methyl-phenylamine

المذيبات

water

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةat reflux temperature for 15 hours
2. 2
   workup.ADDITIONis added
3. 3
   استخلاصthe reaction mixture is extracted with ethylacetate
4. 4
   تجفيفAfter drying of the organic phase over sodium sulfate and evaporation of the solvent in a water jet vacuum
5. 5
   أخرىthe product is purified by destillation (bp. ca. 70° C., 13,33 Pa)

الإجراء التجريبي

2,21 g (10.77 mmol) N-(2-methyl-3-(1,1-dimethylpropyl)phenyl)form-amide, 1,42 g (21.54 mmol) 85% potassium hydroxide and 9 ml methanol are heated under stirring at reflux temperature for 15 hours. After cooling 100 ml of water is added and the reaction mixture is extracted with ethylacetate. After drying of the organic phase over sodium sulfate and evaporation of the solvent in a water jet vacuum, the product is purified by destillation (bp. ca. 70° C., 13,33 Pa). This gives 1.7 g of 2-Methyl-3-(1,1-dimethylpropyl)phenylamine in the form of a colourless oil (89% of theory).

المصدر