تفاعل #586100

معادلة التفاعل

product

2-(2-Nitrophenyl)-3-(trimethylsilyl)-2-propene

hydrogen

→

2-(2-aminophenyl)-3-(trimethylsilyl)-propane

المردود 88.0%

المذيبات

tetrahydrofurane

ظروف التفاعل

المعالجة

1. 1
   ترشيحThe catalyst was filtered off
2. 2
   أخرىafter evaporation of the solvent
3. 3
   أخرىthe product was chromatographed on silacagel (eluent: 10% ethylacetate in hexane)

الإجراء التجريبي

The reaction product of step A [7.2 g] was hydrogenated in tetrahydrofurane over palladium on charcoal at atmospheric pressure and room temperature until the uptake of hydrogen ceased. The catalyst was filtered off and, after evaporation of the solvent, the product was chromatographed on silacagel (eluent: 10% ethylacetate in hexane) to yield 2-(2-aminophenyl)-3-(trimethylsilyl)-propane [4.7 g; 88% purity according to NMR]. This product was used in the next step without further purification.

المصدر