تفاعل #58461

معادلة التفاعل

diisopropylethylamine

N-Benzyl-2-bromomethylpiperidine

5-(4-fluoro-phenyl)-2H-tetrazole

potassium carbonate

→

(RS)-1-Benzyl-2-[5-(4fluoro-phenyl)tetrazol-2-ylmethyl]-piperidine

المذيبات

xylene

ظروف التفاعل

المعالجة

1. 1
   ترشيحfiltered
2. 2
   أخرىsolvent removed at reduced pressure
3. 3
   أخرىthe residue column chromatographed (silica gel; diethyl ether/petroleum ether 40:60 eluant)
4. 4
   أخرىto give
5. 5
   أخرىremoving solvent at reduced pressure the title compound 1.44 g

الإجراء التجريبي

N-Benzyl-2-bromomethylpiperidine (2.1 g), 5-(4-fluoro-phenyl)-2H-tetrazole (1.28 g) and potassium carbonate (6 g) were combined in xylene (100 ml) containing diisopropylethylamine (7 ml) and boiled for 16 h. The reaction mixture was cooled to room temperature, filtered, solvent removed at reduced pressure and the residue column chromatographed (silica gel; diethyl ether/petroleum ether 40:60 eluant) to give after combining appropriate fractions and removing solvent at reduced pressure the title compound 1.44 g.

المصدر