تفاعل #58456

ord-a69345c2ff894388ba7cfbf63ca39edd

معادلة التفاعل

CC(C)(C)OC(=O)N1CCCCC1CC(=O)O
(RS)-2-carboxymethyl-piperidine-1-carboxylic acid tert butyl ester
O=C(CBr)c1ccccc1
2-bromoacetophenone
→
CC(C)(C)OC(=O)N1CCCCC1CC(=O)OCC(=O)c1ccccc1
title compound
المردود 95.2%
CC(C)(C)OC(=O)N1CCCCC1CC(=O)OCC(=O)c1ccccc1
(RS)-2-[2-phenyl-2-oxo-ethoxycarbonylmethyl]-piperidine-1-carboxylic tert butyl ester
المردود 95.2%

المتفاعلات

CC(C)(C)OC(=O)N1CCCCC1CC(=O)O
(RS)-2-carboxymethyl-piperidine-1-carboxylic acid tert butyl ester
O=C(CBr)c1ccccc1
2-bromoacetophenone

الكواشف

لا شيء

ظروف التفاعل

الظروف التفصيلية
See reaction.notes.procedure_details.

الإجراء التجريبي

The title compound (7.07 g) was prepared from (RS)-2-carboxymethyl-piperidine-1-carboxylic acid tert butyl ester (5.0 g) and 2-bromoacetophenone (4.18 g) according to the method of description 36.

المصدر

DOI: 10.6084/m9.figshare.5104873.v1براءة الاختراع: US07423052B2uspto-grants-2008_09