تفاعل #58453

ord-d216e57dc2b64ee0860d42691a2c3596

معادلة التفاعل

CC(C)(C)OC(=O)N1CCCCC1CC(=O)O
2-carboxymethyl-piperidine-1-carboxylic acid tert butyl ester
NCC(=O)c1ccccc1
2-amino-1-phenylethanone
→
CC(C)(C)OC(=O)N1CCCCC1CC(=O)NCC(=O)c1ccccc1
title compound
المردود 85.0%
CC(C)(C)OC(=O)N1CCCCC1CC(=O)NCC(=O)c1ccccc1
(RS)-2-{[2-phenyl-2-oxo-ethylcarbamoyl]-methyl}-piperidine-1-carboxylic acid tert butyl ester
المردود 85.0%

المتفاعلات

CC(C)(C)OC(=O)N1CCCCC1CC(=O)O
2-carboxymethyl-piperidine-1-carboxylic acid tert butyl ester
NCC(=O)c1ccccc1
2-amino-1-phenylethanone

الكواشف

لا شيء

ظروف التفاعل

الظروف التفصيلية
See reaction.notes.procedure_details.

الإجراء التجريبي

The title compound (0.63 g) was prepared from 2-carboxymethyl-piperidine-1-carboxylic acid tert butyl ester (0.50 g) and 2-amino-1-phenylethanone (0.35 g) according to the method of description 54.

المصدر

DOI: 10.6084/m9.figshare.5104873.v1براءة الاختراع: US07423052B2uspto-grants-2008_09