تفاعل #58421

ord-06dfe7381dc5433d95e2da75f0c5647d

معادلة التفاعل

COc1cc(C)c(F)cc1C(=O)c1ccc(Cl)nc1N
(2-Amino-6-chloro-pyridin-3-yl)-(5-fluoro-2-methoxy-4-methyl-phenyl)-methanone
CCOC(=O)N1CCC(N)CC1
ethyl-4-amino- 1-piperidine carboxylate
CCOC(=O)N1CCC(Nc2ccc(C(=O)c3cc(F)c(C)cc3OC)c(N)n2)CC1
title compound
CCOC(=O)N1CCC(Nc2ccc(C(=O)c3cc(F)c(C)cc3OC)c(N)n2)CC1
4-[6-Amino-5-(5-fluoro-2-methoxy-4-methyl-benzoyl)-pyridin-2-ylamino]-piperidine-1-carboxylic acid ethyl ester

ظروف التفاعل

الظروف التفصيلية
See reaction.notes.procedure_details.

الإجراء التجريبي

The title compound was prepared from (2-Amino-6-chloro-pyridin-3-yl)-(5-fluoro-2-methoxy-4-methyl-phenyl)-methanone (Example 43) and ethyl-4-amino- 1-piperidine carboxylate (Aldrich 96%) using the procedure described in Step B. Example 6. HRMS, observed: 431.2090, Calcd for (M+H)+: 431.2089.

المصدر

DOI: 10.6084/m9.figshare.5104873.v1براءة الاختراع: US07423051B2uspto-grants-2008_09