تفاعل #58371

معادلة التفاعل

hydrochloric acid

1-bromo-3-methylbut-2-ene

2-hydroxy-5-methoxybenzaldehyde

potassium carbonate

→

5-methoxy-2-(3 -methylbut-2-enyloxy)benzaldehyde

المذيبات

ethyl acetate

N,N-dimethylformamide

ظروف التفاعل

المعالجة

1. 1
   غسيلthe organic layer was washed with water three times
2. 2
   تجفيفdried over magnesium sulfate
3. 3
   ترشيحThe mixture was filtered
4. 4
   أخرىsolvent removed from the filtrate under reduced pressure

الإجراء التجريبي

To a solution of 2-hydroxy-5-methoxybenzaldehyde (7.6 g, 50 mmol) in dry N,N-dimethylformamide (100 mL) was added potassium carbonate (10.4 g), followed by 1-bromo-3-methylbut-2-ene (10.0 g, 67 mmol). The mixture was stirred at room temperature for 48 hours and ethyl acetate added. Sufficient 1M hydrochloric acid was cautiously added to neutralize the base, and the organic layer was washed with water three times, followed by brine, and dried over magnesium sulfate. The mixture was filtered, and solvent removed from the filtrate under reduced pressure, to provide 5-methoxy-2-(3 -methylbut-2-enyloxy)benzaldehyde.

المصدر