تفاعل #583201

معادلة التفاعل

2-Amino-4,6 dichloropyrimidine

3-fluoro-4-(4-pyridinylthio)-aniline

3-fluoro-4-(4-pyridinylthio)aniline

ammonium hydroxide

→

desired product

المردود 47.4%

N-(2-amino-6-chloro-4-pyrimidinyl)-N-[3-fluoro-4-(4-pyridinylsulfanyl)phenyl]amine

المردود 47.4%

المذيبات

water

ظروف التفاعل

المعالجة

1. 1
   ترشيحThe precipitated yellow product was filtered
2. 2
   غسيلwashed with water
3. 3
   أخرىpurified by column chromatography with 1-3% MeOH in CH2Cl2

الإجراء التجريبي

2-Amino-4,6 dichloropyrimidine (A21, 12 mmol) and 3-fluoro-4-(4-pyridinylthio)-aniline (B7,12 mmol) were suspended in water (150 mL) and treated with 10 drops of concentrated hydrochloric acid. The mixture was stirred at 100° C. overnight. The clear solution was then neutralized with ammonium hydroxide. The precipitated yellow product was filtered, washed with water, and purified by column chromatography with 1-3% MeOH in CH2Cl2 to give the desired product as a white solid (1.98 g, 47%).

المصدر