تفاعل #582502

معادلة التفاعل

1CW01

4-(Tetrahydro-pyran-2-yloxy)-benzaldehyde

NaOH

Cyclopentanone

benzaldehyde

→

solid

المردود 74.0%

2,5-Bis-[4-(tetrahydro-pyran-2-yloxy)-benzylidene]-cyclopentanone

المردود 74.0%

المذيبات

water

ethanol

ethanol

ظروف التفاعل

المعالجة

1. 1
   workup.ADDITIONThis was then added to the THP
2. 2
   workup.WAITthe mixture was left
3. 3
   workup.STIRRINGto stir at room temperature for approximately 16 hours
4. 4
   أخرىA solid precipitate was isolated by vacuum filtration
5. 5
   غسيلwashed with water (2×50 ml)
6. 6
   أخرىThis solid was recrystallised from ethanol

الإجراء التجريبي

Cyclopentanone (8.8 ml, 0.099 mol) was dissolved in ethanol (12 ml) and added to NaOH dissolved in water (25 ml) and ethanol (7 ml), and was left to stir for 25 min. This was then added to the THP protected benzaldehyde from 1CW01 (46.12 g, 0.22 mol), and the mixture was left to stir at room temperature for approximately 16 hours. A solid precipitate was isolated by vacuum filtration, washed with water (2×50 ml) and then ethanol (4×40 ml). This solid was recrystallised from ethanol to give a yellow solid (33.74 g, 74%).

المصدر