تفاعل #58186

ord-cac1865cb15f4dab82dc8f76eb3c6111

معادلة التفاعل

CC(C)c1cc(O)nc(-c2cccc([N+](=O)[O-])c2)n1
6-isopropyl-2-(3-nitro-phenyl)-pyrimidin-4-ol
CC(C)c1cc(O)nc(-c2cccc([N+](=O)[O-])c2)n1
Intermediate 8
CC(C)c1cc(O)nc(-c2cccc([N+](=O)[O-])c2)n1
6-isopropyl-2-(3-nitro-phenyl)-pyrimidin-4-ol
N#Cc1ccc(CBr)cc1
4-cyanobenzyl bromide
→
CC(C)c1cc(OCc2ccc(C#N)cc2)nc(-c2cccc([N+](=O)[O-])c2)n1
title compound
CC(C)c1cc(OCc2ccc(C#N)cc2)nc(-c2cccc([N+](=O)[O-])c2)n1
4-({[6-isopropyl-2-(3-nitrophenyl)pyrimidin-4-yl]oxy}methyl)benzonitrile

المتفاعلات

CC(C)c1cc(O)nc(-c2cccc([N+](=O)[O-])c2)n1
6-isopropyl-2-(3-nitro-phenyl)-pyrimidin-4-ol
CC(C)c1cc(O)nc(-c2cccc([N+](=O)[O-])c2)n1
Intermediate 8
CC(C)c1cc(O)nc(-c2cccc([N+](=O)[O-])c2)n1
6-isopropyl-2-(3-nitro-phenyl)-pyrimidin-4-ol
N#Cc1ccc(CBr)cc1
4-cyanobenzyl bromide

الكواشف

لا شيء

ظروف التفاعل

الظروف التفصيلية
See reaction.notes.procedure_details.

الإجراء التجريبي

The title compound was prepared from 6-isopropyl-2-(3-nitro-phenyl)-pyrimidin-4-ol (which was obtained in Intermediate 8) and 4-cyanobenzyl bromide according to Method A; LC retention time 3.71 min; MS: m/z (ESI) 375 (M+H).

المصدر

DOI: 10.6084/m9.figshare.5104873.v1براءة الاختراع: US07423044B2uspto-grants-2008_09