تفاعل #581579
ord-f18133ff32a94861ad943a2bc72733b4
معادلة التفاعل
المتفاعلات
الكواشف
لا شيء
ظروف التفاعل
الظروف التفصيلية
See reaction.notes.procedure_details.
المعالجة
- 1درجة الحرارةcooling
- 2غسيلThe reaction mixture was washed with 2N hydrochloric acid and saturated brine
- 3تجفيفdried over sodium sulfate
- 4تركيزconcentrated
الإجراء التجريبي
4-Aminobenzoic acid ethyl ester (0.568 g) and triethylamine (0.570 g) were dissolved in methylene chloride (20 mL), and to this solution was dropwise added a solution of 4′-trifluoromethylbiphenyl-2-carboxylic acid chloride, which is prepared from 4′-trifluoromethylbiphenyl-2-carboxylic acid (1.00 g) in a similar manner to Example 1d), in methylene chloride under ice-cooling. The solution was stirred at room temperature for 2 hours, followed by addition of methylene chloride (100 mL). The reaction mixture was washed with 2N hydrochloric acid and saturated brine, dried over sodium sulfate and concentrated to give the title compound (1.43 g).