تفاعل #58152

معادلة التفاعل

2-(acetamino)phenylacetic acid

5,6-diamino-1-[2-(4-nitrophenyl)ethyl]-3-propyluracil

5,6-Diamino-1-[2-(4-nitrophenyl)ethyl]-3-propyluracil

→

8-(2-acetaminobenzyl)-3-[2-(4-nitrophenyl)ethyl]-1-propylxanthine

ظروف التفاعل

الإجراء التجريبي

By the method of Example 2, 2-(acetamino)phenylacetic acid is reacted with 5,6-diamino-1-[2-(4-nitrophenyl)ethyl]-3-propyluracil (6) to yield 8-(2-acetaminobenzyl)-3-[2-(4-nitrophenyl)ethyl]-1-propylxanthine. By methods well known in the art, 8-(2-acetaminobenzyl)-3-[2-(4-nitrophenyl)ethyl]-1-propylxanthine is reduced with hydrazine hydrate or hydrogen gas in the presence of a palladium catalyst to yield 8-(2-acetaminobenzyl)-3-[2-(4-aminophenyl)ethyl]-1-propylxanthine.

المصدر