تفاعل #58140

معادلة التفاعل

N,N-bis(2-chloroethyl)amine hydrochloride

benzyl bromide

triethylamine

→

N,N-Bis(2-chloroethyl)benzylamine

المذيبات

DMF

ظروف التفاعل

المعالجة

1. 1
   أخرىAn ice bath is used
2. 2
   درجة الحرارةto cool
3. 3
   workup.WAITthe mixture is left
4. 4
   تركيزThe reaction mixture is concentrated under vacuum
5. 5
   استخلاصextracted 3 times with ether
6. 6
   تجفيفthe organic phases are dried over Na2SO4
7. 7
   أخرىthe solvent is evaporated under vacuum

الإجراء التجريبي

An ice bath is used to cool a mixture of 150 g of N,N-bis(2-chloroethyl)amine hydrochloride and 100 ml of benzyl bromide in 1000 ml of DMF and then 120 ml of triethylamine are added dropwise and the mixture is left with stirring at AT overnight. The reaction mixture is concentrated under vacuum, the residue is taken up in water and extracted 3 times with ether, the organic phases are dried over Na2SO4 and the solvent is evaporated under vacuum. This gives 113 g of the expected product.

المصدر