تفاعل #58028

معادلة التفاعل

4-(2-hydroxy-ethyl)-piperidine-1-carboxylic acid tert-butyl ester

Diethyl ether

→

4-(2-Oxo-ethyl)-piperidine-1-carboxylic acid tert-butyl ester

المردود 57.1%

المذيبات

CH2Cl2

ظروف التفاعل

المعالجة

1. 1
   أخرىprecipitates
2. 2
   أخرىwere removed by extraction with 10% Na2S2O3/saturated NaHCO3 (1:1, 350 mL)
3. 3
   غسيلThe organic layer was washed with 0.5 M NaOH solution and brine
4. 4
   أخرىThe organic phase was dried
5. 5
   تركيزconcentrated under reduced pressure

الإجراء التجريبي

Periodinane (36.1 g, 85.2 mmol) was added to 4-(2-hydroxy-ethyl)-piperidine-1-carboxylic acid tert-butyl ester (15.0 g, 65.5 mmol) in CH2Cl2 (230 mL) and stirred for 90 min. Diethyl ether (560 ml) was added and precipitates were removed by extraction with 10% Na2S2O3/saturated NaHCO3 (1:1, 350 mL). The organic layer was washed with 0.5 M NaOH solution and brine. The organic phase was dried and concentrated under reduced pressure to yield 4-(2-Oxo-ethyl)-piperidine-1-carboxylic acid tert-butyl ester (8.50 g, 57%).

المصدر