تفاعل #579926

معادلة التفاعل

benzyl (2-fluoro-4-{2-[3-methyl-3-(1-methylpiperidin-4-yl)ureido]pyridin-4-yloxy}phenyl)carbamate

→

3-[4-(4-Amino-3-fluorophenoxy)pyridin-2-yl]-1-methyl-1-(1-methylpiperidin-4-yl)urea

المذيبات

tetrahydrofuran

ظروف التفاعل

المعالجة

1. 1
   ترشيحThe reaction mixture was filtered
2. 2
   أخرىto remove the catalyst, which
3. 3
   غسيلwas then washed with tetrahydrofuran
4. 4
   تجفيفThe filtrate was dried over anhydrous sodium sulfate
5. 5
   تركيزconcentrated to a volume of 40 ml
6. 6
   أخرىto give a solution of the target compound in tetrahydrofuran (40 ml) as a pale yellow solution
7. 7
   أخرىthe solution was used for a next reaction

الإجراء التجريبي

To a solution of benzyl (2-fluoro-4-{2-[3-methyl-3-(1-methylpiperidin-4-yl)ureido]pyridin-4-yloxy}phenyl)carbamate (110 mg) in tetrahydrofuran (10 ml) was 10% palladium carbon (46.2 mg), followed by stirring under a hydrogen atmosphere at room temperature for 18 hrs. The reaction mixture was filtered to remove the catalyst, which was then washed with tetrahydrofuran. The filtrate was dried over anhydrous sodium sulfate, and concentrated to a volume of 40 ml to give a solution of the target compound in tetrahydrofuran (40 ml) as a pale yellow solution. Assuming that the reaction preceded quantitatively, the solution was used for a next reaction.

المصدر