تفاعل #577171

معادلة التفاعل

PyBroP

4′-Trifluoromethyl-biphenyl-2-carboxylic acid

1-ethyl-5-nitro-1H-indole-2-carboxylic acid ethyl ester

DIEA

→

title compound

المردود 54.4%

1-Ethyl-5-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-1H-indole-2-carboxylic acid ethyl ester

المردود 54.4%

المذيبات

DCM

ظروف التفاعل

المعالجة

1. 1
   workup.STIRRINGThe reaction mixture was stirred for another 3 hours
2. 2
   ترشيحThe precipitate was filtered off
3. 3
   غسيلwashed with cold DCM

الإجراء التجريبي

4′-Trifluoromethyl-biphenyl-2-carboxylic acid (5.04 g, 18.95 mmol) and 1-ethyl-5-nitro-1H-indole-2-carboxylic acid ethyl ester (4.00 g, 17.23 mmol) were dissolved in DCM (100 mL). DIEA (8 g, 61.8 mmol) was added to the above mixture and the mixture was stirred at room temperature for 5 minutes. PyBroP (9.63 g, 20.67 mmol) was added to the above solution in one portion. The reaction mixture was stirred for another 3 hours. The precipitate was filtered off and washed with cold DCM to provide the title compound (4.5 g, 54.4%).

المصدر