تفاعل #57696

معادلة التفاعل

5-iodo-4-hydroxy-3-methyl-benzofuran-2-carboxylic acid tert-butyl ester

iodomethane

K2CO3

→

5-iodo-4-methoxy-3-methyl-benzofuran-2-carboxylic acid tert-butyl ester

المردود 101.8%

المذيبات

DMF

ظروف التفاعل

المعالجة

1. 1
   غسيلThe reaction mixture was washed with brine
2. 2
   استخلاصextracted with ethyl acetate
3. 3
   غسيلThe combined ethyl acetate layers were washed with brine
4. 4
   أخرىRemoval of the solvent

الإجراء التجريبي

To 748 mg (2 mmol) of 5-iodo-4-hydroxy-3-methyl-benzofuran-2-carboxylic acid tert-butyl ester was added 1.42 g (10 mmol) of iodomethane, 553 mg (4 mmol) of K2CO3 and 10 mL of DMF. The mixture was stirred at room temperature overnight. The reaction mixture was washed with brine and extracted with ethyl acetate. The combined ethyl acetate layers were washed with brine. Removal of the solvent gave 790 mg (100% yield) of 5-iodo-4-methoxy-3-methyl-benzofuran-2-carboxylic acid tert-butyl ester as a pale brown oil.

المصدر