تفاعل #57667

معادلة التفاعل

5,7-dichloro-4-hydroxy-3-methyl-benzofuran-2-carboxylic acid ethyl ester

iodomethane

K2CO3

→

5,7-dichloro-4-methoxy-3-methyl-benzofuran-2-carboxylic acid ethyl ester

المردود 99.3%

المذيبات

DMF

ظروف التفاعل

المعالجة

1. 1
   غسيلThe mixture was washed with brine
2. 2
   استخلاصextracted with ethyl acetate
3. 3
   غسيلThe combined ethyl acetate solution was washed with brine
4. 4
   أخرىRemoval of the solvent in vacuo

الإجراء التجريبي

To 120 mg of 5,7-dichloro-4-hydroxy-3-methyl-benzofuran-2-carboxylic acid ethyl ester was added 1 mL of iodomethane, 200 mg of K2CO3 and 4 mL of DMF. The mixture was stirred at room temperature overnight. The mixture was washed with brine and extracted with ethyl acetate. The combined ethyl acetate solution was washed with brine. Removal of the solvent in vacuo gave 125 mg (99% yield) of 5,7-dichloro-4-methoxy-3-methyl-benzofuran-2-carboxylic acid ethyl ester as off-white solid.

المصدر