تفاعل #57601

معادلة التفاعل

3-methyl-4-hydroxy-5-ethylbenzofuran carboxylic acid ethyl ester

ethyl 3-methyl-4-hydroxy-5-ethylbenzofuran-2-carboxylate

2-bromopropane

→

5-ethyl-4-isopropoxy-3-methylbenzofuran-2-carboxylic acid ethyl ester

المردود 89.7%

ظروف التفاعل

الإجراء التجريبي

According to the procedure of Example 86, Step 3 0.200 g (0.81 mmol) of 3-methyl-4-hydroxy-5-ethylbenzofuran carboxylic acid ethyl ester (Example 86, Step 2) and 0.379 mL (4.03 mmol) of 2-bromopropane gave 0.211 g of 5-ethyl-4-isopropoxy-3-methylbenzofuran-2-carboxylic acid ethyl ester after chromatography on silica gel eluting with ethyl acetate/hexanes (1:20).

المصدر