تفاعل #5760

معادلة التفاعل

water

2-(1-methylethyl)-5,9-dimethyl-2,4,8-decatrienenitril

diisobutylaluminium hydride

→

2-(1-methylethyl)-5,9-dimethyl-2,4,8-decatrienal

المردود 90.0%

المذيبات

n-hexane

toluene

ظروف التفاعل

المعالجة

1. 1
   workup.ADDITIONwas added to the mixture
2. 2
   أخرىfollowed by removal of the cooling bath and vigorous stirring
3. 3
   أخرىThe resultant while precipitates
4. 4
   ترشيحwere filtered
5. 5
   غسيلwashed with n-hexane
6. 6
   workup.STIRRINGstirred for 3 hours
7. 7
   استخلاصThe organic layer was extracted
8. 8
   أخرىseparated
9. 9
   غسيلwashed with water
10. 10
    تجفيفdried over MgSO4
11. 11
    تركيزconcentrated

الإجراء التجريبي

To a solution of 2-(1-methylethyl)-5,9-dimethyl-2,4,8-decatrienenitril (2Z compound, 217 mg, 1 mmol) in n-hexane (4 ml) was added a 1 M solution of diisobutylaluminium hydride in toluene (2 ml) with stirring under argon atmosphere at -70° C. After two-hour-stirring at the same temperature, water (0.8 ml) was added to the mixture followed by removal of the cooling bath and vigorous stirring. The resultant while precipitates were filtered and washed with n-hexane. The filtrate was combined with a 10% aqueous solution of oxalic acid and stirred for 3 hours. The organic layer was extracted and separated, washed with water, dried over MgSO4, and concentrated. The above manipulation was conducted under argon atmosphere. The resultant residue was subjected to silica gel column chromatography (solvent: n-hexane/ethyl acetate=50:1) to obtain the aimed 2-(1-methylethyl)-5,9-dimethyl-2,4,8-decatrienal (198 mg, 90%).

المصدر